Anti-Human SETD7 Polyclonal Antibody (HP870014)

Name: Anti-Human SETD7 Polyclonal Antibody
Brand: abinScience
SKU: HP870014
Price: 168 USD
Availability: InStock

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概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号

HP870014

説明

Anti-Human SETD7 Polyclonal Antibody (HP870014) is a rabbit polyclonal antibody detecting SETD7 in ELISA, IHC, WB. Suitable for Human, Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

種反応性

Human, Mouse

アプリケーション

ELISA, IHC, WB

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

免疫原

E. coli - derived recombinant Human SETD7 (Met1-Lys366).

ターゲット

Lysine N-methyltransferase 7, SET9, SET7/9, Histone H3-K4 methyltransferase SETD7, SET7, SET domain-containing protein 7, SETD7, H3-K4-HMTase SETD7, KIAA1717, Histone-lysine N-methyltransferase SETD7, KMT7

精製

Purified by antigen affinity column.

アクセッション番号

Q8WTS6

形態

Liquid

保存バッファー

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。

製品使用情報

アプリケーション	希釈
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

安定性と保存

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Histone-lysine N-methyltransferase SETD7 is a ~40 kDa protein. Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Also has methyltransferase activity toward non-histone proteins such as CGAS, p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins.

1. Wang, H. et al. (2001) Molecular cell 8, 1207-17. PMID: 11779497

2. Nishioka, K. et al. (2002) Genes & development 16, 479-89. PMID: 11850410

3. Xiao, B. et al. (2003) Nature 421, 652-6. PMID: 12540855

4. Martens, JH. et al. (2003) Molecular and cellular biology 23, 1808-16. PMID: 12588998

5. Francis, J. et al. (2005) The Journal of biological chemistry 280, 36244-53. PMID: 16141209

9. Xiao, Y. et al. (2022) Bone research 10, 19. PMID: 35210392

注意事項

For research use only.

イメージ

参考文献

データシート

Anti-Human SETD7 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

組換えタンパク質

抗体

アッセイキット

Anti-Human SETD7 Polyclonal Antibody (HP870014)

概要

イメージ

参考文献

データシート

SDS