中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HS767014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human SF3B3 Polyclonal Antibody (HS767014) is a rabbit polyclonal antibody detecting SF3B3 in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
|
||||||||
| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SF3B3 (Met1-Ala362). | ||||||||
| ターゲット | STAF130, KIAA0017, SF3B3, Splicing factor 3B subunit 3, SF3b130, Pre-mRNA-splicing factor SF3b 130 kDa subunit, SAP130, SAP 130, Spliceosome-associated protein 130 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q15393 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||||||
| 製品使用情報 |
| ||||||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Splicing factor 3B subunit 3 (SF3B3) is a ~135 kDa protein. Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3B3 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA. Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. 1. Das, BK. et al. (1999) Molecular and cellular biology 19, 6796-802. PMID: 10490618 2. Das, R. et al. (2000) Molecular cell 5, 779-87. PMID: 10882114 3. Will, CL. et al. (2002) The EMBO journal 21, 4978-88. PMID: 12234937 4. Cretu, C. et al. (2016) Molecular cell 64, 307-319. PMID: 27720643 5. Bertram, K. et al. (2017) Cell 170, 701-713.e11. PMID: 28781166 6. Zhang, Z. et al. (2020) Nature 583, 310-313. PMID: 32494006 7. Tholen, J. et al. (2022) Science (New York, N.Y.) 375, 50-57. PMID: 34822310 | ||||||||
| 注意事項 | For research use only. |
お問い合わせ
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
