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| カタログ番号 | HF762014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human SGPL1 Polyclonal Antibody (HF762014) is a rabbit polyclonal antibody detecting SGPL1. Suitable for Human.
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SGPL1 (Ser122-Tyr550). | ||||||||
| ターゲット | EC:4.1.2.27, KIAA1252, S1PL, SGPL1, SP-lyase 1, SPL 1, Sphingosine-1-phosphate aldolase, Sphingosine-1-phosphate lyase 1, hSPL | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O95470, Q8R0X7 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | Sphingosine-1-phosphate lyase 1 (SGPL1) is a ~63 kDa protein. Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP. 1. Van Veldhoven, PP. et al. (2000) Biochimica et biophysica acta 1487, 128-34. PMID: 11018465 2. Reiss, U. et al. (2004) The Journal of biological chemistry 279, 1281-90. PMID: 14570870 3. Weiler, S. et al. (2014) Journal of medicinal chemistry 57, 5074-84. PMID: 24809814 4. Lovric, S. et al. (2017) The Journal of clinical investigation 127, 912-928. PMID: 28165339 | ||||||||
| 注意事項 | For research use only |
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