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| カタログ番号 | HF717035 |
|---|---|
| 説明 |
Anti-Human SH2D1A Monoclonal Antibody (1A652) [1A652] (HF717035) is a mouse monoclonal antibody detecting SH2D1A in ELISA, IHC, WB. Suitable for Human.
Highlights
|
| 種反応性 | Human |
| アプリケーション | ELISA, IHC, WB |
| 宿主種 | Mouse |
| クローン性 | Monoclonal |
| アイソタイプ | IgG |
| クローンID | 1A652 |
| 免疫原 | E. coli - derived recombinant human SH2D1A (Asp2-Pro97). |
| ターゲット | SH2 domain-containing protein 1A, Duncan disease SH2-protein, Signaling lymphocytic activation molecule-associated protein, SLAM-associated protein, T-cell signal transduction molecule SAP, SH2D1A |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >95% as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | O60880 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 背景 | SH2 domain-containing protein 1A (SH2D1A) is a ~14 kDa protein. Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1. Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. 1. Howie, D. et al. (2002) Blood 99, 957-65. PMID: 11806999 2. Li, C. et al. (2003) The Journal of biological chemistry 278, 3852-9. PMID: 12458214 |
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human SH2D1A Monoclonal Antibody (1A652)
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