Anti-Human SH2D1A Monoclonal Antibody (1A652) (HF717035)

Name: Anti-Human SH2D1A Monoclonal Antibody (1A652)
Brand: abinScience
SKU: HF717035
Price: 194 USD
Availability: InStock

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Каталожный номер	HF717035
Описание	Anti-Human SH2D1A Monoclonal Antibody (1A652) [1A652] (HF717035) is a mouse monoclonal antibody detecting SH2D1A in ELISA, IHC, WB. Suitable for Human. Highlights ●Recombinant — Superior batch-to-batch reproducibility with defined sequences. ●Multi-Application — Validated across multiple applications.
Реактивность видов	Human
Применения	ELISA, IHC, WB
Хозяинский вид	Mouse
Клоональность	Monoclonal
Изотип	IgG
ID клона	1A652
Иммуноген	E. coli - derived recombinant human SH2D1A (Asp2-Pro97).
Цель	SH2 domain-containing protein 1A, Duncan disease SH2-protein, Signaling lymphocytic activation molecule-associated protein, SLAM-associated protein, T-cell signal transduction molecule SAP, SH2D1A
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>95% as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	O60880
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Фон	SH2 domain-containing protein 1A (SH2D1A) is a ~14 kDa protein. Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1. Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. 1. Howie, D. et al. (2002) Blood 99, 957-65. PMID: 11806999 2. Li, C. et al. (2003) The Journal of biological chemistry 278, 3852-9. PMID: 12458214
Примечание	For research use only.

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Anti-Human SH2D1A Monoclonal Antibody (1A652).pdf

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Anti-Human SH2D1A Monoclonal Antibody (1A652) (HF717035)

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