

| Numéro de catalogue | HT138014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-Human SH3BP5 Polyclonal Antibody (HT138014) is a rabbit polyclonal antibody detecting SH3BP5 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| Reactivité des espèces | Human, Mouse, Rat | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human SH3BP5 (Ser10-Glu276). | ||||||||
| Cible | SAB, SH3 domain-binding protein that preferentially associates with BTK, SH3 domain-binding protein 5, SH3BP5, SH3BP-5 | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | O60239 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | SH3 domain-binding protein 5 (SH3BP5) is a ~50 kDa protein. Functions as a guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25. Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death. 1. Sakaguchi, A. et al. (2015) Developmental cell 35, 211-21. PMID: 26506309 2. Jenkins, ML. et al. (2018) Nature communications 9, 3772. PMID: 30217979 | ||||||||
| Note | For research use only. |
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