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| カタログ番号 | HT138014 | ||||||||
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| 説明 |
Anti-Human SH3BP5 Polyclonal Antibody (HT138014) is a rabbit polyclonal antibody detecting SH3BP5 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SH3BP5 (Ser10-Glu276). | ||||||||
| ターゲット | SAB, SH3 domain-binding protein that preferentially associates with BTK, SH3 domain-binding protein 5, SH3BP5, SH3BP-5 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O60239 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | SH3 domain-binding protein 5 (SH3BP5) is a ~50 kDa protein. Functions as a guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25. Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death. 1. Sakaguchi, A. et al. (2015) Developmental cell 35, 211-21. PMID: 26506309 2. Jenkins, ML. et al. (2018) Nature communications 9, 3772. PMID: 30217979 | ||||||||
| 注意事項 | For research use only. |
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