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Anti-Human SH3RF1 Polyclonal Antibody (HD618014)

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Vista general
Número de catálogoHD618014
Descripción
Anti-Human SH3RF1 Polyclonal Antibody (HD618014) is a rabbit polyclonal antibody detecting SH3RF1. Suitable for Human, Rat, and Mouse.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Reactividad de especiesHuman, Mouse, Rat
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human SH3RF1 (Gln135-Lys268).
Objetivo E3 ubiquitin-protein ligase SH3RF1, EC:2.3.2.27, KIAA1494, POSH, POSH1, Plenty of SH3s, Protein POSH, RING finger protein 142, RING-type E3 ubiquitin transferase SH3RF1, RNF142, SH3 domain-containing RING finger protein 1, SH3 multiple domains protein 2, SH3MD2, SH3RF1
Nivel de endotoxinas Please contact with the lab for this information.
Purificación Purified by antigen affinity column.
Número de acceso Q7Z6J0
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Fondo

E3 ubiquitin-protein ligase SH3RF1 is a ~93 kDa protein. Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination. Stimulates ubiquitination of potassium channel KCNJ1, enhancing its dynamin-dependent and clathrin-independent endocytosis. Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the differentiation of CD4(+) and CD8(+) T-cells and promotes T-helper 1 (Th1) cell differentiation.

1. Alroy, I. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 1478-83. PMID: 15659549
2. Kärkkäinen, S. et al. (2010) FEBS letters 584, 3867-72. PMID: 20696164
3. Lin, DH. et al. (2009) The Journal of biological chemistry 284, 29614-24. PMID: 19710010
Nota For research use only
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Human SH3RF1 Polyclonal Antibody

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