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Anti-Human SHOC2 Polyclonal Antibody (HP134014)

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Aperçu
Numéro de catalogueHP134014
Description
Anti-Human SHOC2 Polyclonal Antibody (HP134014) is a rabbit polyclonal antibody detecting SHOC2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactivité des espècesHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human SHOC2 (Ser86-Val582).
Cible Leucine-rich repeat protein SHOC-2, KIAA0862, Protein sur-8 homolog, Protein soc-2 homolog, SHOC2
Purification Purified by antigen affinity column.
Numéro d'accès Q9UQ13
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

Leucine-rich repeat protein SHOC-2 (SHOC2) is a ~64 kDa protein. Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates activation of the MAPK pathway. Acts as a scaffolding protein in the SMP complex. The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities. The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c.

1. Li, W. et al. (2000) Genes & development 14, 895-900. PMID: 10783161
2. Rodriguez-Viciana, P. et al. (2006) Molecular cell 22, 217-30. PMID: 16630891
3. Hannig, V. et al. (2014) Human mutation 35, 1290-4. PMID: 25137548
4. Liau, NPD. et al. (2022) Nature 609, 400-407. PMID: 35768504
5. Hauseman, ZJ. et al. (2022) Nature 609, 416-423. PMID: 35830882
6. Kwon, JJ. et al. (2022) Nature 609, 408-415. PMID: 35831509
7. Bonsor, DA. et al. (2022) Nature structural & molecular biology 29, 966-977. PMID: 36175670
Note For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Formula
C₁ × V₁ = C₂ × V₂
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Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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Anti-Human SHOC2 Polyclonal Antibody

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