

| Каталожный номер | HT426014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Реактивность видов | Human, Mouse, Rat | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human SIAH2 (Ser68-Pro324). | ||||||||
| Цель | RING-type E3 ubiquitin transferase SIAH2, SIAH2, hSiah2, Seven in absentia homolog 2, Siah-2, E3 ubiquitin-protein ligase SIAH2 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | O43255 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | E3 ubiquitin-protein ligase SIAH2 is a ~34 kDa protein. E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (GPS2, POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia. 1. Boehm, J. et al. (2001) The EMBO journal 20, 4153-62. PMID: 11483518 2. Szargel, R. et al. (2009) The Journal of biological chemistry 284, 11706-16. PMID: 19224863 3. Hu, G. et al. (1997) Genes & development 11, 2701-14. PMID: 9334332 | ||||||||
| Примечание | For research use only. |
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