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Anti-Human SLC13A3 Polyclonal Antibody (HB405014)

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Vista general
Número de catálogoHB405014
Descripción
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactividad de especiesHuman
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant human SLC13A3 (Ile158-Ile230).
Objetivo Na(+)/dicarboxylate cotransporter 3; NaDC-3; hNaDC3; Na(+)-coupled carboxylate transporter 3; NaC3; Sodium-dependent high-affinity dicarboxylate transporter 2; Solute carrier family 13 member 3; SLC13A3; SLC13A3; NADC3; SDCT2
Nivel de endotoxinas Please contact with the lab for this information.
Purificación Purified by antigen affinity column.
Número de acceso Q8WWT9
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Na(+)/dicarboxylate cotransporter 3 (SLC13A3) is a ~66 kDa protein. High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-6 carbon atoms, such as the citric acid cycle intermediates succinate and alpha-ketoglutarate (2-oxoglutarate), as well as other compounds including N-acetyl-L-aspartate. Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate, rendering the process electrogenic. Can transport citrate in a Na(+)-dependent manner, recognizing the divalent form of citrate rather than the trivalent form which is normally found in blood. Imports itaconate in hepatocytes leading to activation of TFEB-dependent lysosomal biogenesis involved in antibacterial innate immune response.

1. Wang, H. et al. (2000) American journal of physiology. Cell physiology 278, C1019-30. PMID: 10794676
2. Huang, W. et al. (2000) The Journal of pharmacology and experimental therapeutics 295, 392-403. PMID: 10992006
3. Burckhardt, BC. et al. (2005) American journal of physiology. Renal physiology 288, F792-9. PMID: 15561973
4. Stellmer, F. et al. (2007) Journal of molecular medicine (Berlin, Germany) 85, 763-70. PMID: 17356845
5. Bai, XY. et al. (2007) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 21, 2409-17. PMID: 17426067
6. Schorbach, L. et al. (2013) Nephron. Physiology 124, 1-5. PMID: 24247155
7. Dewulf, JP. et al. (2019) Annals of neurology 85, 385-395. PMID: 30635937
8. Li, Y. et al. (2025) Nature structural & molecular biology 32, 502-512. PMID: 39622972
9. Chen, C. et al. (2024) Developmental cell 59, 2807-2817.e8. PMID: 39116875
Nota For research use only
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Datasheet
Download SDS PDF
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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