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| カタログ番号 | HC091013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG | ||||
| クローンID | SAA2355 | ||||
| ターゲット | Solute carrier family 15 member 4, Peptide transporter 4, Peptide/histidine transporter 1, hPHT1, SLC15A4, PHT1, PTR4 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | Q8N697 | ||||
| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 背景 | Solute carrier family 15 member 4 (SLC15A4) is a ~62 kDa protein. Proton-coupled amino-acid transporter that mediates the transmembrane transport of L-histidine and some di- and tripeptides from inside the lysosome to the cytosol, and plays a key role in innate immune response. Preferably binds to short peptides with a basic residue at the first position and a hydrophobic residue at the second position. Able to transport a variety of di- and tripeptides, including carnosine and some peptidoglycans. Transporter activity is pH-dependent and maximized in the acidic lysosomal environment. Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand, and L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate (tri-DAP), the NOD1 ligand. 1. Bhardwaj, RK. et al. (2006) European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 27, 533-42. PMID: 16289537 2. Kobayashi, T. et al. (2014) Immunity 41, 375-388. PMID: 25238095 3. Song, F. et al. (2018) Molecular pharmaceutics 15, 385-393. PMID: 29224352 4. Zhang, Z. et al. (2025) Structure (London, England : 1993) 33, 330-337.e4. PMID: 39719710 5. Oppermann, H. et al. (2019) Amino acids 51, 999-1008. PMID: 31073693 6. Heinz, LX. et al. (2020) Nature 581, 316-322. PMID: 32433612 | ||||
| 注意事項 | For research use only |
SDS-PAGE for Anti-Human SLC15A4 Antibody (SAA2355)
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中国武漢市深敦寺路666号C棟、武漢、430206
