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| カタログ番号 | HX905013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | SAA1576 | ||||
| ターゲット | MCT 1, SLC16A1, Monocarboxylate transporter 1, MCT1, Solute carrier family 16 member 1 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | P53985 | ||||
| RRID | Anti-Human SLC16A1/MCT1 Antibody (SAA1576) (abinScience Cat# HX905013, RRID:AB_3727337) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Monocarboxylate transporter 1 (SLC16A1/MCT1) is a ~53 kDa protein. Bidirectional proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, acetate and the ketone bodies acetoacetate and beta-hydroxybutyrate, and thus contributes to the maintenance of intracellular pH. The transport direction is determined by the proton motive force and the concentration gradient of the substrate monocarboxylate. MCT1 is a major lactate exporter. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis. 1. Galić, S. et al. (2003) The Biochemical journal 376, 413-22. PMID: 12946269 2. Reddy, A. et al. (2020) Cell 183, 62-75.e17. PMID: 32946811 3. Wang, N. et al. (2021) Cell 184, 370-383.e13. PMID: 33333023 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human SLC16A1/MCT1 Antibody (SAA1576)
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