Anti-Human SLC1A5 Recombinant Antibody (SAA0181) (HS734107)

Name: Anti-Human SLC1A5 Recombinant Antibody (SAA0181)
Brand: abinScience
SKU: HS734107
Price: 191 USD
Availability: InStock

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概要
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参考文献
データシート
SDS

概要

カタログ番号	HS734107
種反応性	Human
アプリケーション	FCM
宿主種	Human
クローン性	Monoclonal
アイソタイプ	IgG1, kappa
クローンID	SAA0181
ターゲット	Baboon M7 virus receptor, SLC1A5, Solute carrier family 1 member 5, ASCT2, RDR, RD114/simian type D retrovirus receptor, Sodium-dependent neutral amino acid transporter type 2, ATB(0), Neutral amino acid transporter B(0), M7V1, RDRC
エンドトキシンレベル	Please contact with the lab for this information.
純度	>95% as determined by SDS-PAGE.
精製	Protein A/G purified from cell culture supernatant.
アクセッション番号	Q15758
形態	Liquid
保存バッファー	0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
背景	Neutral amino acid transporter B(0) (SLC1A5) is a ~56 kDa protein. Sodium-coupled antiporter of neutral amino acids. In a tri-substrate transport cycle, exchanges neutral amino acids between the extracellular and intracellular compartments, coupled to the inward cotransport of at least one sodium ion. The preferred substrate is the essential amino acid L-glutamine, a precursor for biosynthesis of proteins, nucleotides and amine sugars as well as an alternative fuel for mitochondrial oxidative phosphorylation. Exchanges L-glutamine with other neutral amino acids such as L-serine, L-threonine and L-asparagine in a bidirectional way. Provides L-glutamine to proliferating stem and activated cells driving the metabolic switch toward cell differentiation. 1. Dun, Y. et al. (2007) Experimental eye research 84, 191-9. PMID: 17094966 2. Pingitore, P. et al. (2013) Biochimica et biophysica acta 1828, 2238-46. PMID: 23756778 3. Scalise, M. et al. (2015) FEBS letters 589, 3617-23. PMID: 26492990 4. Garaeva, AA. et al. (2018) Nature structural & molecular biology 25, 515-521. PMID: 29872227 5. Mazza, T. et al. (2021) FEBS letters 595, 3030-3041. PMID: 34741534 6. Kekuda, R. et al. (1996) The Journal of biological chemistry 271, 18657-61. PMID: 8702519 7. Borowska, AM. et al. (2024) Nature communications 15, 6570. PMID: 39095408 8. Foster, AC. et al. (2016) PloS one 11, e0156551. PMID: 27272177 9. Oburoglu, L. et al. (2014) Cell stem cell 15, 169-84. PMID: 24953180
注意事項	For research use only.

イメージ

Flow Cytometry

Flow-cytometry using anti-human SLC1A5 antibody.HeLa cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human SLC1A5 antibody monoclonal antibody (Catalog # HS734107 ,Green Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a FITC conjugated goat anti-human antibody (Catalog # HF690414) and cells analysed on a NovoCyte Flow Cytometer.
Flow Cytometry

Flow-cytometry using anti-human SLC1A5 antibody.A431 cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human SLC1A5 antibody monoclonal antibody (Catalog # HS734107 ,Green Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a FITC conjugated goat anti-human antibody (Catalog # HF690414) and cells analysed on a NovoCyte Flow Cytometer.