Anti-Human SLC22A12 Polyclonal Antibody (HP208014)

Name: Anti-Human SLC22A12 Polyclonal Antibody
Brand: abinScience
SKU: HP208014
Price: 168 USD
Availability: InStock

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Especificación:

50ug
100ug

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HP208014

Reactividad de especies

Human

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human SLC22A12 (Glu281-Thr350).

Objetivo

Urate anion exchanger 1, Organic anion transporter 4-like protein, OATL4, Solute carrier family 22 member 12, RST, URAT1, SLC22A12, Renal-specific transporter

Purificación

Purified by antigen affinity column.

Número de acceso

Q96S37

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Solute carrier family 22 member 12 (SLC22A12) is a ~59 kDa protein. Electroneutral antiporter that translocates urate across the apical membrane of proximal tubular cells in exchange for monovalent organic or inorganic anions. Involved in renal reabsorption of urate and helps maintaining blood levels of uric acid. Mediates urate uptake by an exchange with organic anions such as (S)-lactate and nicotinate, and inorganic anion Cl(-). Other inorganic anions such as Br(-), I(-) and NO3(-) may also act as counteranions that exchange for urate. Also mediates orotate tubular uptake coupled with nicotinate efflux and to a lesser extent with lactate efflux, therefore displaying a potential role in orotate renal reabsorption.

1. Enomoto, A. et al. (2002) Nature 417, 447-52. PMID: 12024214

2. Tasic, V. et al. (2011) PloS one 6, e28641. PMID: 22194875

3. Shinoda, Y. et al. (2022) Drug metabolism and pharmacokinetics 43, 100443. PMID: 35144162

4. Toyoda, Y. et al. (2022) Frontiers in pharmacology 13, 842717. PMID: 35462902

5. Miura, D. et al. (2011) The journal of physiological sciences : JPS 61, 253-7. PMID: 21350910

Nota

For research use only.

Imágenes

Referencias

Datasheet

Anti-Human SLC22A12 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo