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| カタログ番号 | HP208014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SLC22A12 (Glu281-Thr350). | ||||||||
| ターゲット | Urate anion exchanger 1, Organic anion transporter 4-like protein, OATL4, Solute carrier family 22 member 12, RST, URAT1, SLC22A12, Renal-specific transporter | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q96S37 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Solute carrier family 22 member 12 (SLC22A12) is a ~59 kDa protein. Electroneutral antiporter that translocates urate across the apical membrane of proximal tubular cells in exchange for monovalent organic or inorganic anions. Involved in renal reabsorption of urate and helps maintaining blood levels of uric acid. Mediates urate uptake by an exchange with organic anions such as (S)-lactate and nicotinate, and inorganic anion Cl(-). Other inorganic anions such as Br(-), I(-) and NO3(-) may also act as counteranions that exchange for urate. Also mediates orotate tubular uptake coupled with nicotinate efflux and to a lesser extent with lactate efflux, therefore displaying a potential role in orotate renal reabsorption. 1. Enomoto, A. et al. (2002) Nature 417, 447-52. PMID: 12024214 2. Tasic, V. et al. (2011) PloS one 6, e28641. PMID: 22194875 3. Shinoda, Y. et al. (2022) Drug metabolism and pharmacokinetics 43, 100443. PMID: 35144162 4. Toyoda, Y. et al. (2022) Frontiers in pharmacology 13, 842717. PMID: 35462902 5. Miura, D. et al. (2011) The journal of physiological sciences : JPS 61, 253-7. PMID: 21350910 | ||||||||
| 注意事項 | For research use only. |
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