Anti-Human SLC22A6 Polyclonal Antibody (HS924014)

Name: Anti-Human SLC22A6 Polyclonal Antibody
Brand: abinScience
SKU: HS924014
Price: 168 USD
Availability: InStock

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50ug
100ug

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Número de catálogo

HS924014

Descripción

Anti-Human SLC22A6 Polyclonal Antibody (HS924014) is a rabbit polyclonal antibody detecting SLC22A6 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactividad de especies

Human

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human SLC22A6 (Thr41-Arg131).

Objetivo

hROAT1, PAH transporter, Solute carrier family 22 member 6, PAHT, Renal organic anion transporter 1, hPAHT, OAT1, SLC22A6, Organic anion transporter 1, hOAT1

Purificación

Purified by antigen affinity column.

Número de acceso

Q4U2R8

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Solute carrier family 22 member 6 (SLC22A6) is a ~61 kDa protein. Secondary active transporter that functions as a Na(+)-independent organic anion (OA)/dicarboxylate antiporter where the uptake of one molecule of OA into the cell is coupled with an efflux of one molecule of intracellular dicarboxylate such as 2-oxoglutarate or glutarate. Mediates the uptake of OA across the basolateral side of proximal tubule epithelial cells, thereby contributing to the renal elimination of endogenous OA from the systemic circulation into the urine. Functions as a biopterin transporters involved in the uptake and the secretion of coenzymes tetrahydrobiopterin (BH4), dihydrobiopterin (BH2) and sepiapterin to urine, thereby determining baseline levels of blood biopterins. Transports prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may contribute to their renal excretion. Also mediates the uptake of cyclic nucleotides such as cAMP and cGMP.

1. Jung, KY. et al. (2001) Life sciences 69, 2123-35. PMID: 11669456

2. Kimura, H. et al. (2002) The Journal of pharmacology and experimental therapeutics 301, 293-8. PMID: 11907186

3. Deguchi, T. et al. (2004) Kidney international 65, 162-74. PMID: 14675047

4. Uwai, Y. et al. (2012) Pharmacological research 65, 254-60. PMID: 22108572

5. Uwai, Y. et al. (2013) Bioscience, biotechnology, and biochemistry 77, 1517-21. PMID: 23832370

6. Ohashi, A. et al. (2017) Molecular and cellular biochemistry 435, 97-108. PMID: 28534121

7. Lu, R. et al. (1999) The American journal of physiology 276, F295-303. PMID: 9950961

8. Hosoyamada, M. et al. (1999) The American journal of physiology 276, F122-8. PMID: 9887087

Nota

For research use only.

Imágenes

Referencias

Datasheet

Anti-Human SLC22A6 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo

Anti-Human SLC22A6 Polyclonal Antibody (HS924014)

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Imágenes

Referencias

Datasheet

SDS