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| カタログ番号 | HS924014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human SLC22A6 Polyclonal Antibody (HS924014) is a rabbit polyclonal antibody detecting SLC22A6 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SLC22A6 (Thr41-Arg131). | ||||||||
| ターゲット | hROAT1, PAH transporter, Solute carrier family 22 member 6, PAHT, Renal organic anion transporter 1, hPAHT, OAT1, SLC22A6, Organic anion transporter 1, hOAT1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q4U2R8 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Solute carrier family 22 member 6 (SLC22A6) is a ~61 kDa protein. Secondary active transporter that functions as a Na(+)-independent organic anion (OA)/dicarboxylate antiporter where the uptake of one molecule of OA into the cell is coupled with an efflux of one molecule of intracellular dicarboxylate such as 2-oxoglutarate or glutarate. Mediates the uptake of OA across the basolateral side of proximal tubule epithelial cells, thereby contributing to the renal elimination of endogenous OA from the systemic circulation into the urine. Functions as a biopterin transporters involved in the uptake and the secretion of coenzymes tetrahydrobiopterin (BH4), dihydrobiopterin (BH2) and sepiapterin to urine, thereby determining baseline levels of blood biopterins. Transports prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may contribute to their renal excretion. Also mediates the uptake of cyclic nucleotides such as cAMP and cGMP. 1. Jung, KY. et al. (2001) Life sciences 69, 2123-35. PMID: 11669456 2. Kimura, H. et al. (2002) The Journal of pharmacology and experimental therapeutics 301, 293-8. PMID: 11907186 3. Deguchi, T. et al. (2004) Kidney international 65, 162-74. PMID: 14675047 4. Uwai, Y. et al. (2012) Pharmacological research 65, 254-60. PMID: 22108572 5. Uwai, Y. et al. (2013) Bioscience, biotechnology, and biochemistry 77, 1517-21. PMID: 23832370 6. Ohashi, A. et al. (2017) Molecular and cellular biochemistry 435, 97-108. PMID: 28534121 7. Lu, R. et al. (1999) The American journal of physiology 276, F295-303. PMID: 9950961 8. Hosoyamada, M. et al. (1999) The American journal of physiology 276, F122-8. PMID: 9887087 | ||||||||
| 注意事項 | For research use only. |
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