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| カタログ番号 | HF639014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human SLC25A12 Polyclonal Antibody (HF639014) is a rabbit polyclonal antibody detecting SLC25A12 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SLC25A12 (Gly11-Gln311). | ||||||||
| ターゲット | Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial, Araceli hiperlarga, Aralar, Aralar1, Mitochondrial aspartate glutamate carrier 1, Solute carrier family 25 member 12, SLC25A12, AGC1, ARALAR1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O75746 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial is a ~74 kDa protein. Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle. Also mediates the uptake of L-cysteinesulfinate (3-sulfino-L-alanine) by mitochondria in exchange of L-glutamate and proton. Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation. Lacks transport activity towards L-glutamine or gamma-aminobutyric acid (GABA). 1. Palmieri, L. et al. (2001) The EMBO journal 20, 5060-9. PMID: 11566871 2. Wibom, R. et al. (2009) The New England journal of medicine 361, 489-95. PMID: 19641205 3. Falk, MJ. et al. (2014) JIMD reports 14, 77-85. PMID: 24515575 4. Porcelli, V. et al. (2024) Biochimica et biophysica acta. Bioenergetics 1865, 149487. PMID: 38945283 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-SLC25A12 polyclonal antibody at SLC25A12 on various samples.
Lane 1: Jurkat cell lysate
Lane 2: A431 cell lysate
Lane 3: Mouse brain lysate
Lane 4: Mouse skeletal muscle lysate
Lane 5: Rat brain lysate
Lane 6: Rat skeletal muscle lysate
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