

| Numéro de catalogue | HV071014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Reactivité des espèces | Human | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human SLC26A8 (Thr664-Val970). | ||||||||
| Cible | Solute carrier family 26 member 8, SLC26A8, Testis anion transporter 1, TAT1, Anion exchange transporter | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | Q96RN1 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | Testis anion transporter 1 (SLC26A8) is a ~109 kDa protein. Antiporter that mediates the exchange of sulfate and oxalate against chloride ions across a membrane. Stimulates anion transport activity of CFTR. May cooperate with CFTR in the regulation of chloride and bicarbonate ions fluxes required for activation of the ADCY10/PKA pathway during sperm motility and sperm capacitation. May play a role in sperm tail differentiation and motility and hence male fertility. 1. Toure, A. et al. (2001) The Journal of biological chemistry 276, 20309-15. PMID: 11278976 2. Lohi, H. et al. (2002) The Journal of biological chemistry 277, 14246-54. PMID: 11834742 3. Rode, B. et al. (2012) Human molecular genetics 21, 1287-98. PMID: 22121115 4. Dirami, T. et al. (2013) American journal of human genetics 92, 760-6. PMID: 23582645 | ||||||||
| Note | For research use only. |
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