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| カタログ番号 | HT300014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human SLC27A2 Polyclonal Antibody (HT300014) is a rabbit polyclonal antibody detecting SLC27A2 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SLC27A2 (Gly283-Leu620). | ||||||||
| ターゲット | Long-chain fatty acid transport protein 2, Arachidonate--CoA ligase, 6.2.1.15, Fatty acid transport protein 2, FATP-2, Fatty-acid-coenzyme A ligase, very long-chain 1, Long-chain-fatty-acid--CoA ligase, 6.2.1.3, Phytanate--CoA ligase, 6.2.1.24, Solute carrier family 27 member 2, THCA-CoA ligase, 6.2.1.7, Very long-chain acyl-CoA synthetase, VLACS, VLCS, 6.2.1.-, Very long-chain-fatty-acid-CoA ligase, SLC27A2, ACSVL1, FACVL1, FATP2, VLACS | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O14975 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Long-chain fatty acid transport protein 2 (SLC27A2) is a ~70 kDa protein. Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport across cell membranes, playing an important role in hepatic fatty acid uptake. Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. Can also activate branched-chain fatty acids such as phytanic acid and pristanic acid. May contribute to the synthesis of sphingosine-1-phosphate. 1. Steinberg, SJ. et al. (1999) Biochemical and biophysical research communications 257, 615-21. PMID: 10198260 2. Steinberg, SJ. et al. (2000) The Journal of biological chemistry 275, 15605-8. PMID: 10749848 3. Mihalik, SJ. et al. (2002) The Journal of biological chemistry 277, 24771-9. PMID: 11980911 4. Falcon, A. et al. (2010) American journal of physiology. Endocrinology and metabolism 299, E384-93. PMID: 20530735 5. Krammer, J. et al. (2011) International journal of medical sciences 8, 599-614. PMID: 22022213 6. Ohkuni, A. et al. (2013) Biochemical and biophysical research communications 442, 195-201. PMID: 24269233 | ||||||||
| 注意事項 | For research use only. |
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