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| カタログ番号 | HC035014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human SLC31A1 Polyclonal Antibody (HC035014) is a rabbit polyclonal antibody detecting High affinity copper uptake protein 1; Copper transporter 1; hCTR1; Solute carrier family 31 member 1; Truncated CTR1 form; SLC31A1; COPT1; CTR1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant human SLC31A1 (Asp2-Leu61&Tyr83-His132). | ||||||||
| ターゲット | High affinity copper uptake protein 1; Copper transporter 1; hCTR1; Solute carrier family 31 member 1; Truncated CTR1 form; SLC31A1; COPT1; CTR1 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O15431 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | High affinity copper uptake protein 1 (SLC31A1) is a ~21 kDa protein. Uniporter that mediates the transport of copper(1+) from the extracellular space to the cytoplasm, across the plasma membrane and delivers directly copper(1+) to specific chaperone such as ATOX1, via a copper(1+)- mediated transient interaction between the C-terminal domain and a copper(1+) chaperone, thus controlling intracellular copper(1+) levels. May function in copper(1+) import from the apical membrane thus may drive intestinal copper absorption. The copper(1+) transport mechanism is sodium-independent, saturable and of high-affinity. Also mediates the uptake of silver(1+). May function in the influx of the platinum-containing chemotherapeutic agents. 1. Lee, J. et al. (2002) The Journal of biological chemistry 277, 4380-7. PMID: 11734551 2. Eisses, JF. et al. (2005) The Journal of biological chemistry 280, 37159-68. PMID: 16135512 3. Maryon, EB. et al. (2007) The Journal of biological chemistry 282, 20376-87. PMID: 17525160 4. Molloy, SA. et al. (2009) The Journal of biological chemistry 284, 29704-13. PMID: 19740744 5. Larson, CA. et al. (2010) Biochemical pharmacology 80, 448-54. PMID: 20451502 6. Bertinato, J. et al. (2010) Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 24, 178-84. PMID: 20569931 7. Maryon, EB. et al. (2013) The Journal of biological chemistry 288, 18035-46. PMID: 23658018 | ||||||||
| 注意事項 | For research use only |
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