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| カタログ番号 | HD636014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human SLC39A7 Polyclonal Antibody (HD636014) is a rabbit polyclonal antibody detecting SLC39A7. Suitable for Human.
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SLC39A7 (Gly30-Thr133). | ||||||||
| ターゲット | HKE4, Histidine-rich membrane protein Ke4, RING5, Really interesting new gene 5 protein, SLC39A7, Solute carrier family 39 member 7, ZIP7, Zinc transporter SLC39A7, Zrt-, Irt-like protein 7 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q92504 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | Zinc transporter SLC39A7 is a ~50 kDa protein. Transports Zn(2+) from the endoplasmic reticulum (ER)/Golgi apparatus to the cytosol, playing an essential role in the regulation of cytosolic zinc levels. Acts as a gatekeeper of zinc release from intracellular stores, requiring post-translational activation by phosphorylation, resulting in activation of multiple downstream pathways leading to cell growth and proliferation. Has an essential role in B cell development and is required for proper B cell receptor signaling. Plays an important role in maintaining intestinal epithelial homeostasis and skin dermis development by regulating ER function. Controls cell signaling pathways involved in glucose metabolism in skeletal muscle. 1. Taylor, KM. et al. (2004) The Biochemical journal 377, 131-9. PMID: 14525538 2. Huang, L. et al. (2005) The Journal of biological chemistry 280, 15456-63. PMID: 15705588 3. Nimmanon, T. et al. (2017) Metallomics : integrated biometal science 9, 471-481. PMID: 28205653 4. Woodruff, G. et al. (2018) Molecular pharmacology 94, 1092-1100. PMID: 29980658 5. Taylor, KM. et al. (2012) Science signaling 5, ra11. PMID: 22317921 6. Anzilotti, C. et al. (2019) Nature immunology 20, 350-361. PMID: 30718914 7. Fauster, A. et al. (2019) Cell death and differentiation 26, 1138-1155. PMID: 30237509 | ||||||||
| 注意事項 | For research use only |
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