Anti-Human SLC5A8 Recombinant Antibody (SAA0314), FITC (HP275117)

Name: Anti-Human SLC5A8 Recombinant Antibody (SAA0314), FITC
Brand: abinScience
SKU: HP275117
Price: 196 USD
Availability: InStock

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Numéro de catalogue	HP275117
Reactivité des espèces	Human
Applications	ELISA, FCM
Espèce hôte	Mouse
Clonalité	Monoclonal
Isotype	VHH-mFC
ID de clone	SAA0314
Conjugaison	FITC
Cible	Apical iodide transporter, Sodium-coupled monocarboxylate transporter 1, SMCT1, AIT, Sodium iodide-related cotransporter, SMCT, Solute carrier family 5 member 8, Electrogenic sodium monocarboxylate cotransporter, SLC5A8
Niveau d'endotoxines	Please contact with the lab for this information.
Produits associés	VHH-mFc Isotype Control antibody (cAb-Lys2), FITC
Numéro d'accès	Q8N695
Forme	Liquid
Tampon de stockage	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Contexte	Sodium-coupled monocarboxylate transporter 1 (SLC5A8) is a ~66 kDa protein. Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. 1. Miyauchi, S. et al. (2004) The Journal of biological chemistry 279, 13293-6. PMID: 14966140 2. Coady, MJ. et al. (2004) The Journal of physiology 557, 719-31. PMID: 15090606 3. Itagaki, S. et al. (2006) Pharmaceutical research 23, 1209-16. PMID: 16729224 4. Martin, PM. et al. (2006) Journal of neurochemistry 98, 279-88. PMID: 16805814 5. Thangaraju, M. et al. (2006) Cancer research 66, 11560-4. PMID: 17178845 6. Gopal, E. et al. (2007) Pharmaceutical research 24, 575-84. PMID: 17245649 7. Coady, MJ. et al. (2007) Biophysical journal 93, 2325-31. PMID: 17526579 8. Miyauchi, S. et al. (2010) Biochimica et biophysica acta 1798, 1164-71. PMID: 20211600 9. Srivastava, S. et al. (2019) The journal of physiological sciences : JPS 69, 399-408. PMID: 30604288 10. Rodriguez, AM. et al. (2002) The Journal of clinical endocrinology and metabolism 87, 3500-3. PMID: 12107270
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Human SLC5A8 Recombinant Antibody (SAA0314), FITC.pdf

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