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| カタログ番号 | HP275107 |
|---|---|
| 種反応性 | Human |
| アプリケーション | ELISA, FCM |
| 宿主種 | Mouse |
| クローン性 | Monoclonal |
| アイソタイプ | VHH-mFC |
| クローンID | SAA0314 |
| ターゲット | Apical iodide transporter, Sodium-coupled monocarboxylate transporter 1, SMCT1, AIT, Sodium iodide-related cotransporter, SMCT, Solute carrier family 5 member 8, Electrogenic sodium monocarboxylate cotransporter, SLC5A8 |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >95% as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | Q8N695 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS, pH 7.4, 0.09% Sodium azide. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| 背景 | Sodium-coupled monocarboxylate transporter 1 (SLC5A8) is a ~66 kDa protein. Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. 1. Miyauchi, S. et al. (2004) The Journal of biological chemistry 279, 13293-6. PMID: 14966140 2. Coady, MJ. et al. (2004) The Journal of physiology 557, 719-31. PMID: 15090606 3. Itagaki, S. et al. (2006) Pharmaceutical research 23, 1209-16. PMID: 16729224 4. Martin, PM. et al. (2006) Journal of neurochemistry 98, 279-88. PMID: 16805814 5. Thangaraju, M. et al. (2006) Cancer research 66, 11560-4. PMID: 17178845 6. Gopal, E. et al. (2007) Pharmaceutical research 24, 575-84. PMID: 17245649 7. Coady, MJ. et al. (2007) Biophysical journal 93, 2325-31. PMID: 17526579 8. Miyauchi, S. et al. (2010) Biochimica et biophysica acta 1798, 1164-71. PMID: 20211600 9. Srivastava, S. et al. (2019) The journal of physiological sciences : JPS 69, 399-408. PMID: 30604288 10. Rodriguez, AM. et al. (2002) The Journal of clinical endocrinology and metabolism 87, 3500-3. PMID: 12107270 |
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human SLC5A8 Antibody (SAA0314)
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