Anti-Human SLC7A11 Polyclonal Antibody (HC159014)

Name: Anti-Human SLC7A11 Polyclonal Antibody
Brand: abinScience
SKU: HC159014
Price: 168 USD
Availability: InStock

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Especificación:

50ug
100ug

Número:

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Referencias
Datasheet
SDS

Vista general

Número de catálogo

HC159014

Descripción

Anti-Human SLC7A11 Polyclonal Antibody (HC159014) is a rabbit polyclonal antibody detecting SLC7A11. Suitable for Human.

Reactividad de especies

Human

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human SLC7A11 (Met1-Arg42).

Objetivo

Amino acid transport system xc-, Calcium channel blocker resistance protein CCBR1, Cystine/glutamate transporter, SLC7A11, Solute carrier family 7 member 11, xCT

Nivel de endotoxinas

Please contact with the lab for this information.

Purificación

Purified by antigen affinity column.

Número de acceso

Q9UPY5

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Fondo

Cystine/glutamate transporter (SLC7A11) is a ~55 kDa protein. Heterodimer with SLC3A2, that functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane. Provides L-cystine for the maintenance of the redox balance between extracellular L-cystine and L-cysteine and for the maintenance of the intracellular levels of glutathione that is essential for cells protection from oxidative stress. The transport is sodium-independent, electroneutral with a stoichiometry of 1:1, and is drove by the high intracellular concentration of L-glutamate and the intracellular reduction of L-cystine. Acts as an inhibitor of ferroptosis by mediating the import of L-kynurenine leading to anti-ferroptotic signaling propagation required to maintain L-cystine and glutathione homeostasis. Also inhibits ferroptosis by acting as an atypical proton transporter that mediates a slow proton efflux from lysosomes via cystine and glutamate flux.

1. Bridges, CC. et al. (2001) Investigative ophthalmology & visual science 42, 47-54. PMID: 11133847

2. Bassi, MT. et al. (2001) Pflugers Archiv : European journal of physiology 442, 286-96. PMID: 11417227

3. Jiménez-Vidal, M. et al. (2004) The Journal of biological chemistry 279, 11214-21. PMID: 14722095

4. Gasol, E. et al. (2004) The Journal of biological chemistry 279, 31228-36. PMID: 15151999

5. Parker, JL. et al. (2021) Nature communications 12, 7147. PMID: 34880232

6. Fiore, A. et al. (2022) Molecular cell 82, 920-932.e7. PMID: 35245456

7. Yan, R. et al. (2022) Cell research 32, 687-690. PMID: 35352032

8. Zhang, HL. et al. (2025) Nature chemical biology 21, 1531-1543. PMID: 40246981

Nota

For research use only

Imágenes

Referencias

Datasheet

Anti-Human SLC7A11 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

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