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| カタログ番号 | HC159014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human SLC7A11 Polyclonal Antibody (HC159014) is a rabbit polyclonal antibody detecting SLC7A11. Suitable for Human.
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SLC7A11 (Met1-Arg42). | ||||||||
| ターゲット | Amino acid transport system xc-, Calcium channel blocker resistance protein CCBR1, Cystine/glutamate transporter, SLC7A11, Solute carrier family 7 member 11, xCT | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9UPY5 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | Cystine/glutamate transporter (SLC7A11) is a ~55 kDa protein. Heterodimer with SLC3A2, that functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane. Provides L-cystine for the maintenance of the redox balance between extracellular L-cystine and L-cysteine and for the maintenance of the intracellular levels of glutathione that is essential for cells protection from oxidative stress. The transport is sodium-independent, electroneutral with a stoichiometry of 1:1, and is drove by the high intracellular concentration of L-glutamate and the intracellular reduction of L-cystine. Acts as an inhibitor of ferroptosis by mediating the import of L-kynurenine leading to anti-ferroptotic signaling propagation required to maintain L-cystine and glutathione homeostasis. Also inhibits ferroptosis by acting as an atypical proton transporter that mediates a slow proton efflux from lysosomes via cystine and glutamate flux. 1. Bridges, CC. et al. (2001) Investigative ophthalmology & visual science 42, 47-54. PMID: 11133847 2. Bassi, MT. et al. (2001) Pflugers Archiv : European journal of physiology 442, 286-96. PMID: 11417227 3. Jiménez-Vidal, M. et al. (2004) The Journal of biological chemistry 279, 11214-21. PMID: 14722095 4. Gasol, E. et al. (2004) The Journal of biological chemistry 279, 31228-36. PMID: 15151999 5. Parker, JL. et al. (2021) Nature communications 12, 7147. PMID: 34880232 6. Fiore, A. et al. (2022) Molecular cell 82, 920-932.e7. PMID: 35245456 7. Yan, R. et al. (2022) Cell research 32, 687-690. PMID: 35352032 8. Zhang, HL. et al. (2025) Nature chemical biology 21, 1531-1543. PMID: 40246981 | ||||||||
| 注意事項 | For research use only |
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