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| カタログ番号 | HW453014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human SLCO1A2 Polyclonal Antibody (HW453014) is a rabbit polyclonal antibody detecting SLCO1A2. Suitable for Human.
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SLCO1A2 (Phe406-Phe513). | ||||||||
| ターゲット | OATP, OATP-1, OATP-A, OATP1, OATP1A2, Organic anion-transporting polypeptide 1, SLC21A3, SLCO1A2, Sodium-independent organic anion transporter, Solute carrier family 21 member 3, Solute carrier organic anion transporter family member 1A2 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P46721 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | Solute carrier organic anion transporter family member 1A2 (SLCO1A2) is a ~74 kDa protein. Na(+)-independent transporter that mediates the cellular uptake of a broad range of organic anions such as the endogenous bile salts cholate and deoxycholate, either in their unconjugated or conjugated forms (taurocholate and glycocholate), at the plasmam membrane. Responsible for intestinal absorption of bile acids. Transports dehydroepiandrosterone 3-sulfate (DHEAS), a major circulating steroid secreted by the adrenal cortex, as well as estrone 3-sulfate and 17beta-estradiol 17-O-(beta-D-glucuronate). Mediates apical uptake of all-trans-retinol (atROL) across human retinal pigment epithelium, which is essential to maintaining the integrity of the visual cycle and thus vision. Involved in the uptake of clinically used drugs. 1. Leuthold, S. et al. (2009) American journal of physiology. Cell physiology 296, C570-82. PMID: 19129463 2. Kullak-Ublick, GA. et al. (1995) Gastroenterology 109, 1274-82. PMID: 7557095 3. Kullak-Ublick, GA. et al. (2001) Gastroenterology 120, 525-33. PMID: 11159893 4. Briz, O. et al. (2003) The Biochemical journal 371, 897-905. PMID: 12568656 5. Zhou, F. et al. (2013) The AAPS journal 15, 1099-108. PMID: 23918469 6. Chan, T. et al. (2015) British journal of pharmacology 172, 2343-53. PMID: 25560245 7. Kullak-Ublick, GA. et al. (1998) FEBS letters 424, 173-6. PMID: 9539145 8. Bailey, DG. et al. (2007) Clinical pharmacology and therapeutics 81, 495-502. PMID: 17301733 | ||||||||
| 注意事項 | For research use only |
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