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| カタログ番号 | HP622014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human SLCO2A1 Polyclonal Antibody (HP622014) is a rabbit polyclonal antibody detecting SLCO2A1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SLCO2A1 (Met418-Ala518). | ||||||||
| ターゲット | OATP2A1, Solute carrier family 21 member 2, Prostaglandin transporter, Solute carrier organic anion transporter family member 2A1, SLCO2A1, SLC21A2, PGT | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q92959 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Solute carrier organic anion transporter family member 2A1 (SLCO2A1) is a ~70 kDa protein. Mediates the transport of prostaglandins (PGs, mainly PGE2, PGE1, PGE3, PGF2alpha, PGD2, PGH2) and thromboxanes (thromboxane B2) across the cell membrane. PGs and thromboxanes play fundamental roles in diverse functions such as intraocular pressure, gastric acid secretion, renal salt and water transport, vascular tone, and fever. Plays a role in the clearance of PGs from the circulation through cellular uptake, which allows cytoplasmic oxidation and PG signal termination. PG uptake is dependent upon membrane potential and involves exchange of a monovalent anionic substrate (PGs exist physiologically as an anionic monovalent form) with a stoichiometry of 1:1 for divalent anions or of 1:2 for monovalent anions. Uses lactate, generated by glycolysis, as a counter-substrate to mediate PGE2 influx and efflux. 1. Chan, BS. et al. (2002) American journal of physiology. Renal physiology 282, F1097-102. PMID: 11997326 2. Gose, T. et al. (2016) Prostaglandins & other lipid mediators 122, 10-7. PMID: 26692285 3. Lu, R. et al. (1996) The Journal of clinical investigation 98, 1142-9. PMID: 8787677 4. Nomura, T. et al. (2004) Molecular pharmacology 65, 973-8. PMID: 15044627 5. Nakanishi, T. et al. (2017) The AAPS journal 20, 13. PMID: 29204966 6. Kang, J. et al. (2006) Human reproduction (Oxford, England) 21, 592-9. PMID: 16339169 | ||||||||
| 注意事項 | For research use only. |
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