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| カタログ番号 | HS868014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human SMN1 Polyclonal Antibody (HS868014) is a rabbit polyclonal antibody detecting SMN1. Suitable for Human.
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SMN1 (Met1-Asn294). | ||||||||
| ターゲット | Component of gems 1, Gemin-1, SMN, SMN1, SMNT, Survival motor neuron protein | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q16637 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | Survival motor neuron protein (SMN1) is a ~31 kDa protein. The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Within the SMN complex, SMN1 acts as a structural backbone and together with GEMIN2 it gathers the Sm complex subunits. 1. Chari, A. et al. (2008) Cell 135, 497-509. PMID: 18984161 2. Pellizzoni, L. et al. (1998) Cell 95, 615-24. PMID: 9845364 3. Otter, S. et al. (2007) The Journal of biological chemistry 282, 5825-33. PMID: 17178713 4. Zhang, R. et al. (2011) Cell 146, 384-95. PMID: 21816274 5. Tripsianes, K. et al. (2011) Nature structural & molecular biology 18, 1414-20. PMID: 22101937 6. Yi, H. et al. (2020) Nucleic acids research 48, 895-911. PMID: 31799625 7. Lotti, F. et al. (2012) Cell 151, 440-54. PMID: 23063131 8. Zhao, DY. et al. (2016) Nature 529, 48-53. PMID: 26700805 | ||||||||
| 注意事項 | For research use only. |
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