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| カタログ番号 | HP388013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA, IF, IP | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a | ||||
| クローンID | SAA0229 | ||||
| ターゲット | HSKM-B, N-lysine methyltransferase SMYD2, Histone methyltransferase SMYD2, SMYD2, SET and MYND domain-containing protein 2, Lysine N-methyltransferase 3C, KMT3C | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | Q9NRG4 | ||||
| RRID | Anti-Human SMYD2 IP Antibody (SAA0229) (abinScience Cat# HP388013, RRID:AB_3729763) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | N-lysine methyltransferase SMYD2 is a ~49 kDa protein. Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human SMYD2 IP Antibody (SAA0229)
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