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| カタログ番号 | HF649014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human SNAPIN Polyclonal Antibody (HF649014) is a rabbit polyclonal antibody detecting SNAPIN in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SNAPIN (Gly21-Lys136). | ||||||||
| ターゲット | Synaptosomal-associated protein 25-binding protein, SNAPIN, Biogenesis of lysosome-related organelles complex 1 subunit 7, SNARE-associated protein Snapin, BLOC-1 subunit 7, BLOC1S7, SNAPAP, SNAP25BP, SNAP-associated protein | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O95295 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | SNARE-associated protein Snapin (SNAPAP) is a ~14 kDa protein. Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. 1. Setty, SR. et al. (2007) Molecular biology of the cell 18, 768-80. PMID: 17182842 2. Granata, A. et al. (2008) The Journal of biological chemistry 283, 7568-79. PMID: 18167355 3. Pu, J. et al. (2015) Developmental cell 33, 176-88. PMID: 25898167 | ||||||||
| 注意事項 | For research use only. |
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