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Anti-Human SNU13 Polyclonal Antibody (HX240014)

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Aperçu
Numéro de catalogueHX240014
Description
Anti-Human SNU13 Polyclonal Antibody (HX240014) is a rabbit polyclonal antibody detecting SNU13 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactivité des espècesHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human SNU13 (Met1-Val128).
Cible High mobility group-like nuclear protein 2 homolog 1, SNU13, U4/U6.U5 tri-snRNP 15.5 kDa protein, OTK27, hSNU13, SNU13 homolog, U4/U6.U5 small nuclear ribonucleoprotein SNU13, NHP2-like protein 1, NHP2L1
Purification Purified by antigen affinity column.
Numéro d'accès P55769
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

NHP2-like protein 1 (SNU13) is a ~14 kDa protein. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in pre-mRNA splicing as component of the spliceosome. Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly. The protein undergoes a conformational change upon RNA-binding.

1. Singh, S. et al. (2021) Science (New York, N.Y.) 373, eabj5338. PMID: 34516797
2. Bertram, K. et al. (2017) Cell 170, 701-713.e11. PMID: 28781166
3. Nottrott, S. et al. (1999) The EMBO journal 18, 6119-33. PMID: 10545122
4. Liu, S. et al. (2007) Science (New York, N.Y.) 316, 115-20. PMID: 17412961
5. Zhang, D. et al. (2024) Proceedings of the National Academy of Sciences of the United States of America 121, e2406961121. PMID: 39570315
Note For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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