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| カタログ番号 | HC628014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human SNX1 Polyclonal Antibody (HC628014) is a rabbit polyclonal antibody detecting SNX1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SNX1 (Phe143-Ser522). | ||||||||
| ターゲット | Sorting nexin-1, SNX1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q13596 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Sorting nexin-1 (SNX1) is a ~59 kDa protein. Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). 1. Cozier, GE. et al. (2002) The Journal of biological chemistry 277, 48730-6. PMID: 12198132 2. Bhatia, VK. et al. (2009) The EMBO journal 28, 3303-14. PMID: 19816406 3. van Weering, JR. et al. (2012) The EMBO journal 31, 4466-80. PMID: 23085988 4. Carlton, J. et al. (2004) Current biology : CB 14, 1791-800. PMID: 15498486 5. Rojas, R. et al. (2007) Molecular and cellular biology 27, 1112-24. PMID: 17101778 6. Bujny, MV. et al. (2007) Journal of cell science 120, 2010-21. PMID: 17550970 7. Mari, M. et al. (2008) Traffic (Copenhagen, Denmark) 9, 380-93. PMID: 18088323 8. Kim, E. et al. (2010) Biochemical and biophysical research communications 403, 167-71. PMID: 21040701 9. Gullapalli, A. et al. (2006) Molecular biology of the cell 17, 1228-38. PMID: 16407403 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-SNX1 polyclonal antibody at 1μg/ml on various samples.
Lane 1: U87 cell lysate
Lane 2: DU145 cell lysate
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