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Anti-Human SNX17 Polyclonal Antibody (HC387014)

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Vista general
Número de catálogoHC387014
Descripción
Anti-Human SNX17 Polyclonal Antibody (HC387014) is a rabbit polyclonal antibody detecting SNX17 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Pongo abelii.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactividad de especiesHuman, Mouse, Rat
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human SNX17 (Met1-Gly401).
Objetivo KIAA0064, SNX17, Sorting nexin-17
Purificación Purified by antigen affinity column.
Número de acceso Q15036
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Sorting nexin-17 (SNX17) is a ~52 kDa protein. Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits. Also required for maintenance of normal cell surface levels of APP and LRP1. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).

1. Williams, R. et al. (2004) Molecular biology of the cell 15, 3095-105. PMID: 15121882
2. Knauth, P. et al. (2005) Journal of molecular biology 347, 813-25. PMID: 15769472
3. Singla, A. et al. (2024) Nature communications 15, 10193. PMID: 39587083
4. Ghai, R. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 7763-8. PMID: 21512128
5. Steinberg, F. et al. (2012) The Journal of cell biology 197, 219-30. PMID: 22492727
6. McNally, KE. et al. (2017) Nature cell biology 19, 1214-1225. PMID: 28892079
7. Czubayko, M. et al. (2006) Biochemical and biophysical research communications 345, 1264-72. PMID: 16712798
8. Donoso, M. et al. (2009) Molecular biology of the cell 20, 481-97. PMID: 19005208
Nota For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Human SNX17 Polyclonal Antibody

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