

| Каталожный номер | HC387014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Human SNX17 Polyclonal Antibody (HC387014) is a rabbit polyclonal antibody detecting SNX17 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Pongo abelii.
Highlights
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| Реактивность видов | Human, Mouse, Rat | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human SNX17 (Met1-Gly401). | ||||||||
| Цель | KIAA0064, SNX17, Sorting nexin-17 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q15036 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Sorting nexin-17 (SNX17) is a ~52 kDa protein. Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits. Also required for maintenance of normal cell surface levels of APP and LRP1. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)). 1. Williams, R. et al. (2004) Molecular biology of the cell 15, 3095-105. PMID: 15121882 2. Knauth, P. et al. (2005) Journal of molecular biology 347, 813-25. PMID: 15769472 3. Singla, A. et al. (2024) Nature communications 15, 10193. PMID: 39587083 4. Ghai, R. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 7763-8. PMID: 21512128 5. Steinberg, F. et al. (2012) The Journal of cell biology 197, 219-30. PMID: 22492727 6. McNally, KE. et al. (2017) Nature cell biology 19, 1214-1225. PMID: 28892079 7. Czubayko, M. et al. (2006) Biochemical and biophysical research communications 345, 1264-72. PMID: 16712798 8. Donoso, M. et al. (2009) Molecular biology of the cell 20, 481-97. PMID: 19005208 | ||||||||
| Примечание | For research use only. |
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