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| カタログ番号 | HT141014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human SNX2 Polyclonal Antibody (HT141014) is a rabbit polyclonal antibody detecting SNX2 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SNX2 (Asp125-Ser277). | ||||||||
| ターゲット | Sorting nexin-2, Transformation-related gene 9 protein, TRG-9, SNX2, TRG9 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O60749 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Sorting nexin-2 (SNX2) is a ~58 kDa protein. Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). 1. Carlton, JG. et al. (2005) Journal of cell science 118, 4527-39. PMID: 16179610 2. Rojas, R. et al. (2007) Molecular and cellular biology 27, 1112-24. PMID: 17101778 3. van Weering, JR. et al. (2012) The EMBO journal 31, 4466-80. PMID: 23085988 4. Lieu, ZZ. et al. (2010) European journal of cell biology 89, 379-93. PMID: 20138391 5. Prosser, DC. et al. (2010) Traffic (Copenhagen, Denmark) 11, 1347-62. PMID: 20604901 | ||||||||
| 注意事項 | For research use only. |
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