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| カタログ番号 | HT384014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human SOCS1 Polyclonal Antibody (HT384014) is a rabbit polyclonal antibody detecting SOCS1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SOCS1 (Ser60-Ile211). | ||||||||
| ターゲット | SOCS-1, SSI-1, JAB, JAK-binding protein, STAT-induced STAT inhibitor 1, Suppressor of cytokine signaling 1, Tec-interacting protein 3, TIP-3, SSI1, SOCS1, TIP3 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O15524 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Suppressor of cytokine signaling 1 (SOCS1) is a ~23 kDa protein. Essential negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF). Downregulates cytokine signaling by inhibiting the JAK/STAT signaling pathway. Acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity. In vitro, suppresses Tec protein-tyrosine activity. Regulates IFN-gamma (IFNG)-mediated sensory neuron survival. 1. Thaventhiran, JED. et al. (2020) Nature 583, 90-95. PMID: 32499645 2. Hadjadj, J. et al. (2020) Nature communications 11, 5341. PMID: 33087723 3. Ohya, Ki. et al. (1997) The Journal of biological chemistry 272, 27178-82. PMID: 9341160 4. Kamizono, S. et al. (2001) The Journal of biological chemistry 276, 12530-8. PMID: 11278610 5. Frantsve, J. et al. (2001) Molecular and cellular biology 21, 3547-57. PMID: 11313480 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-SOCS1 polyclonal antibody at 1ug/mL on various samples.
Lane 1: K562 cell lysate
Lane 2: Hepg2 cell lysate
Lane 3: A549 cell lysate
Lane 4: Mouse spleen lysate
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