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| カタログ番号 | HP190014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human SPAG5 Polyclonal Antibody (HP190014) is a rabbit polyclonal antibody detecting SPAG5 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SPAG5 (Met976-Asp1098). | ||||||||
| ターゲット | Sperm-associated antigen 5, SPAG5, Astrin, Deepest, MAP126, Mitotic spindle-associated protein p126 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q96R06 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Sperm-associated antigen 5 (SPAG5) is a ~134 kDa protein. Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes. 1. Mack, GJ. et al. (2001) Proceedings of the National Academy of Sciences of the United States of America 98, 14434-9. PMID: 11724960 2. Gruber, J. et al. (2002) Journal of cell science 115, 4053-9. PMID: 12356910 3. Chu, X. et al. (2016) The Journal of biological chemistry 291, 20055-67. PMID: 27462074 4. Thein, KH. et al. (2007) The Journal of cell biology 178, 345-54. PMID: 17664331 5. Du, J. et al. (2008) Biochemical and biophysical research communications 370, 213-9. PMID: 18361916 6. Dunsch, AK. et al. (2011) The Journal of cell biology 192, 959-68. PMID: 21402792 7. Kodani, A. et al. (2015) eLife 4. PMID: 26297806 8. Thedieck, K. et al. (2013) Cell 154, 859-74. PMID: 23953116 9. Cheng, TS. et al. (2008) The Journal of biological chemistry 283, 2454-64. PMID: 18055457 | ||||||||
| 注意事項 | For research use only. |
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