

| Каталожный номер | HP190014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Human SPAG5 Polyclonal Antibody (HP190014) is a rabbit polyclonal antibody detecting SPAG5 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Реактивность видов | Human | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human SPAG5 (Met976-Asp1098). | ||||||||
| Цель | Sperm-associated antigen 5, SPAG5, Astrin, Deepest, MAP126, Mitotic spindle-associated protein p126 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q96R06 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Sperm-associated antigen 5 (SPAG5) is a ~134 kDa protein. Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes. 1. Mack, GJ. et al. (2001) Proceedings of the National Academy of Sciences of the United States of America 98, 14434-9. PMID: 11724960 2. Gruber, J. et al. (2002) Journal of cell science 115, 4053-9. PMID: 12356910 3. Chu, X. et al. (2016) The Journal of biological chemistry 291, 20055-67. PMID: 27462074 4. Thein, KH. et al. (2007) The Journal of cell biology 178, 345-54. PMID: 17664331 5. Du, J. et al. (2008) Biochemical and biophysical research communications 370, 213-9. PMID: 18361916 6. Dunsch, AK. et al. (2011) The Journal of cell biology 192, 959-68. PMID: 21402792 7. Kodani, A. et al. (2015) eLife 4. PMID: 26297806 8. Thedieck, K. et al. (2013) Cell 154, 859-74. PMID: 23953116 9. Cheng, TS. et al. (2008) The Journal of biological chemistry 283, 2454-64. PMID: 18055457 | ||||||||
| Примечание | For research use only. |
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