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| カタログ番号 | HA621014 | ||||||||
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| 説明 |
Anti-Human SPRR2A Polyclonal Antibody (HA621014) is a rabbit polyclonal antibody detecting Small proline-rich protein 2A; SPR-2A; 2-1; SPRR2A in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant human SPRR2A (Ser2-Lys72). | ||||||||
| ターゲット | Small proline-rich protein 2A; SPR-2A; 2-1; SPRR2A | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P35326, P35325 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Small proline-rich protein 2A (SPRR2A) is a ~7 kDa protein. Gut bactericidal protein that selectively kills Gram-positive bacteria by binding to negatively charged lipids on bacterial membranes, leading to bacterial membrane permeabilization and disruption. Specifically binds lipids bearing negatively charged headgroups, such as phosphatidic acid, phosphatidylserine (PS), cardiolipin (CL), and phosphatidylinositol phosphates, but not to zwitterionic or neutral lipids. Induced by type-2 cytokines in response to helminth infection and is required to protect against helminth-induced bacterial invasion of intestinal tissue. May also be involved in the development of the cornified envelope of squamous epithelia; however, additional evidences are required to confirm this result in vivo. 1. Hu, Z. et al. (2021) Science (New York, N.Y.) 374, eabe6723. PMID: 34735226 2. Gibbs, S. et al. (1993) Genomics 16, 630-7. PMID: 8325635 | ||||||||
| 注意事項 | For research use only |
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