

| Número de catálogo | HP089014 | ||||||||
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| Descripción |
Anti-Human STAMBPL1/AMSHLP Polyclonal Antibody (HP089014) is a rabbit polyclonal antibody detecting STAMBPL1 in ELISA, IHC, WB. Suitable for Human, Mouse, and Pongo abelii.
Highlights
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| Reactividad de especies | Human, Mouse | ||||||||
| Aplicaciones | ELISA, IHC, WB | ||||||||
| Especie huésped | Rabbit | ||||||||
| Clonalidad | Polyclonal | ||||||||
| Isotipo | IgG | ||||||||
| Inmunógeno | E. coli - derived recombinant Human STAMBPL1/AMSHLP (Arg267-Arg436). | ||||||||
| Objetivo | AMSHLP, AMSH-LP, AMSH-like protease, STAMBPL1, STAM-binding protein-like 1, KIAA1373 | ||||||||
| Purificación | Purified by antigen affinity column. | ||||||||
| Número de acceso | Q96FJ0 | ||||||||
| Forma | Liquid | ||||||||
| Buffer de almacenamiento | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote. |
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| Información de uso del producto |
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| Estabilidad y almacenamiento | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Fondo | AMSH-like protease (STAMBPL1/AMSHLP) is a ~49 kDa protein. Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Acts as a positive regulator of the TORC1 signaling pathway by mediating 'Lys-63'-linked deubiquitination of SESN2, thereby inhibiting SESN2-interaction with the GATOR2 complex. Does not cleave 'Lys-48'-linked polyubiquitin chains. 1. Sato, Y. et al. (2008) Nature 455, 358-62. PMID: 18758443 2. Wang, D. et al. (2022) Molecular cell 82, 770-784.e9. PMID: 35114100 | ||||||||
| Nota | For research use only. |
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