

| Numéro de catalogue | HP089014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-Human STAMBPL1/AMSHLP Polyclonal Antibody (HP089014) is a rabbit polyclonal antibody detecting STAMBPL1 in ELISA, IHC, WB. Suitable for Human, Mouse, and Pongo abelii.
Highlights
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| Reactivité des espèces | Human, Mouse | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human STAMBPL1/AMSHLP (Arg267-Arg436). | ||||||||
| Cible | AMSHLP, AMSH-LP, AMSH-like protease, STAMBPL1, STAM-binding protein-like 1, KIAA1373 | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | Q96FJ0 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | AMSH-like protease (STAMBPL1/AMSHLP) is a ~49 kDa protein. Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Acts as a positive regulator of the TORC1 signaling pathway by mediating 'Lys-63'-linked deubiquitination of SESN2, thereby inhibiting SESN2-interaction with the GATOR2 complex. Does not cleave 'Lys-48'-linked polyubiquitin chains. 1. Sato, Y. et al. (2008) Nature 455, 358-62. PMID: 18758443 2. Wang, D. et al. (2022) Molecular cell 82, 770-784.e9. PMID: 35114100 | ||||||||
| Note | For research use only. |
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