

| Каталожный номер | HC309014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Human STX4 Polyclonal Antibody (HC309014) is a rabbit polyclonal antibody detecting STX4 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Реактивность видов | Human, Mouse, Rat | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human STX4 (Ser36-Leu275). | ||||||||
| Цель | Syntaxin-4, STX4A, Renal carcinoma antigen NY-REN-31, STX4 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q12846 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Syntaxin-4 (STX4) is a ~34 kDa protein. Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. In neurons, recruited at neurite tips to membrane domains rich in the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) which promotes neurite tip surface expression of the dopamine transporter SLC6A3/DAT by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones. Required for normal hearing. 1. Schrauwen, I. et al. (2023) Human molecular genetics 32, 1184-1192. PMID: 36355422 | ||||||||
| Примечание | For research use only. |

Western blot analysis was performed using anti-STX4 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Hela cell lysate
Lane 2: HL-60 cell lysate
Lane 3: K562 cell lysate
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