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| カタログ番号 | HP689014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human SUCLA2 Polyclonal Antibody (HP689014) is a rabbit polyclonal antibody detecting SUCLA2 in ELISA, IHC, WB. Suitable for Human, Mouse, Bovine, Columba livia, and Macaca fascicularis.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SUCLA2 (Ser54-Glu445). | ||||||||
| ターゲット | ATP-specific succinyl-CoA synthetase subunit beta, SCS-betaA, Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial, A-SCS, Succinyl-CoA synthetase beta-A chain, SUCLA2 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9P2R7 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (SUCLA2) is a ~50 kDa protein. ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. Also able to act as an ATP-specific itaconyl- and malyl-CoA synthetase. 1. Elpeleg, O. et al. (2005) American journal of human genetics 76, 1081-6. PMID: 15877282 2. Marcero, JR. et al. (2021) Blood advances 5, 4831-4841. PMID: 34492704 3. Griffith, CM. et al. (2025) Nature chemical biology 21, 906-915. PMID: 40108300 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-SUCLA2 polyclonal antibody at 1μg/ml on various samples.
Lane 1: SH-SY5Y cell lysate
Lane 2: HepG2 cell lysate
Lane 3: PC3 cell lysate
Lane 4: LO2 cell lysate
Lane 5: Hela cell lysate
Lane 6: 293T cell lysate
Lane 7: Mouse brain lysate
Lane 8: Mouse liver lysate
Lane 9: Mouse heart lysate
Lane 10: Mouse spleen lysate
Lane11: Rat brain lysate
Lane12: Rat liver lysate
Lane13: Rat heart lysate
Lane14: Rat spleen lysate
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