Anti-Human SUFU Polyclonal Antibody (HP131014)

Name: Anti-Human SUFU Polyclonal Antibody
Brand: abinScience
SKU: HP131014
Price: 168 USD
Availability: InStock

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Spécification :

50ug
100ug

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Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HP131014

Reactivité des espèces

Human, Mouse

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human SUFU (Gly33-Asn265).

Cible

SUFU, Suppressor of fused homolog, SUFUH

Purification

Purified by antigen affinity column.

Numéro d'accès

Q9UMX1

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Suppressor of fused homolog (SUFU) is a ~53 kDa protein. Negative regulator in the hedgehog/smoothened signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Down-regulates GLI2-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome.

1. Kogerman, P. et al. (1999) Nature cell biology 1, 312-9. PMID: 10559945

2. Stone, DM. et al. (1999) Journal of cell science 112 ( Pt 23), 4437-48. PMID: 10564661

3. Murone, M. et al. (2000) Nature cell biology 2, 310-2. PMID: 10806483

4. Taylor, MD. et al. (2002) Nature genetics 31, 306-10. PMID: 12068298

5. Clark, HF. et al. (2003) Genome research 13, 2265-70. PMID: 12975309

6. Merchant, M. et al. (2004) Molecular and cellular biology 24, 8627-41. PMID: 15367681

7. Chi, S. et al. (2012) Cellular signalling 24, 1222-8. PMID: 22365972

8. Zhang, Y. et al. (2013) Nature communications 4, 2608. PMID: 24217340

9. Cherry, AL. et al. (2013) Acta crystallographica. Section D, Biological crystallography 69, 2563-79. PMID: 24311597

10. Raducu, M. et al. (2016) The EMBO journal 35, 1400-16. PMID: 27234298

Note

For research use only.

Images

Reférences

Fiche technique

Anti-Human SUFU Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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