Anti-Human SUGCT Polyclonal Antibody (HA129014)

Name: Anti-Human SUGCT Polyclonal Antibody
Brand: abinScience
SKU: HA129014
Price: 96 USD
Availability: InStock

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Fiche technique
SDS

Aperçu

Numéro de catalogue

HA129014

Description

Anti-Human SUGCT Polyclonal Antibody (HA129014) is a rabbit polyclonal antibody detecting SUGCT in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactivité des espèces

Human

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human SUGCT (Gln32-His438).

Cible

Succinate--hydroxymethylglutarate CoA-transferase, 2.8.3.13, Dermal papilla-derived protein 13, SuccinylCoA:glutarate-CoA transferase, SUGCT, C7orf10, DERP13

Purification

Purified by antigen affinity column.

Numéro d'accès

Q9HAC7

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Succinyl-CoA:glutarate CoA-transferase (SUGCT) is a ~47 kDa protein. Coenzyme A (CoA) transferase that reversibly catalyzes the transfer of a CoA moiety from a dicarboxyl-CoA to a dicarboxylate in a metabolite recycling process. Displays preference for succinyl-CoA and glutarate-CoA as dicarboxyl-CoA donors and glutarate, succinate, adipate/hexanedioate, itaconate and 3-hydroxy-3-methylglutarate as dicarboxylate acceptors. Acts on intermediates or end products of lysine and tryptophan degradation pathway, in particular catalyzes succinyl-CoA-dependent reesterification of free glutarate into glutaryl-CoA to prevent renal excretion of glutarate. Upon inflammation, may convert macrophage-derived itaconate to itaconyl-CoA in erythroid precursors where it negatively regulates the TCA cycle and heme synthesis to limit erythroid differentiation in the context of stress erythropoiesis.

1. Marlaire, S. et al. (2014) Journal of inherited metabolic disease 37, 13-9. PMID: 23893049

2. Marcero, JR. et al. (2021) Blood advances 5, 4831-4841. PMID: 34492704

3. Wu, R. et al. (2024) ACS chemical biology 19, 1544-1553. PMID: 38915184

4. Sherman, EA. et al. (2008) American journal of human genetics 83, 604-9. PMID: 18926513

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-SYGCT polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse kidney lysate

Reférences

Fiche technique

Anti-Human SUGCT Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai

Anti-Human SUGCT Polyclonal Antibody (HA129014)

Aperçu

Images

Reférences

Fiche technique

SDS