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| カタログ番号 | HA129014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human SUGCT Polyclonal Antibody (HA129014) is a rabbit polyclonal antibody detecting SUGCT in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SUGCT (Gln32-His438). | ||||||||
| ターゲット | Succinate--hydroxymethylglutarate CoA-transferase, 2.8.3.13, Dermal papilla-derived protein 13, SuccinylCoA:glutarate-CoA transferase, SUGCT, C7orf10, DERP13 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9HAC7 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Succinyl-CoA:glutarate CoA-transferase (SUGCT) is a ~47 kDa protein. Coenzyme A (CoA) transferase that reversibly catalyzes the transfer of a CoA moiety from a dicarboxyl-CoA to a dicarboxylate in a metabolite recycling process. Displays preference for succinyl-CoA and glutarate-CoA as dicarboxyl-CoA donors and glutarate, succinate, adipate/hexanedioate, itaconate and 3-hydroxy-3-methylglutarate as dicarboxylate acceptors. Acts on intermediates or end products of lysine and tryptophan degradation pathway, in particular catalyzes succinyl-CoA-dependent reesterification of free glutarate into glutaryl-CoA to prevent renal excretion of glutarate. Upon inflammation, may convert macrophage-derived itaconate to itaconyl-CoA in erythroid precursors where it negatively regulates the TCA cycle and heme synthesis to limit erythroid differentiation in the context of stress erythropoiesis. 1. Marlaire, S. et al. (2014) Journal of inherited metabolic disease 37, 13-9. PMID: 23893049 2. Marcero, JR. et al. (2021) Blood advances 5, 4831-4841. PMID: 34492704 3. Wu, R. et al. (2024) ACS chemical biology 19, 1544-1553. PMID: 38915184 4. Sherman, EA. et al. (2008) American journal of human genetics 83, 604-9. PMID: 18926513 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-SYGCT polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse kidney lysate
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