Anti-Human SUGCT Polyclonal Antibody (HA129014)

Name: Anti-Human SUGCT Polyclonal Antibody
Brand: abinScience
SKU: HA129014
Price: 96 USD
Availability: InStock

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Каталожный номер

HA129014

Описание

Anti-Human SUGCT Polyclonal Antibody (HA129014) is a rabbit polyclonal antibody detecting SUGCT in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Реактивность видов

Human

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human SUGCT (Gln32-His438).

Цель

Succinate--hydroxymethylglutarate CoA-transferase, 2.8.3.13, Dermal papilla-derived protein 13, SuccinylCoA:glutarate-CoA transferase, SUGCT, C7orf10, DERP13

Очистка

Purified by antigen affinity column.

Номер доступа

Q9HAC7

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Succinyl-CoA:glutarate CoA-transferase (SUGCT) is a ~47 kDa protein. Coenzyme A (CoA) transferase that reversibly catalyzes the transfer of a CoA moiety from a dicarboxyl-CoA to a dicarboxylate in a metabolite recycling process. Displays preference for succinyl-CoA and glutarate-CoA as dicarboxyl-CoA donors and glutarate, succinate, adipate/hexanedioate, itaconate and 3-hydroxy-3-methylglutarate as dicarboxylate acceptors. Acts on intermediates or end products of lysine and tryptophan degradation pathway, in particular catalyzes succinyl-CoA-dependent reesterification of free glutarate into glutaryl-CoA to prevent renal excretion of glutarate. Upon inflammation, may convert macrophage-derived itaconate to itaconyl-CoA in erythroid precursors where it negatively regulates the TCA cycle and heme synthesis to limit erythroid differentiation in the context of stress erythropoiesis.

1. Marlaire, S. et al. (2014) Journal of inherited metabolic disease 37, 13-9. PMID: 23893049

2. Marcero, JR. et al. (2021) Blood advances 5, 4831-4841. PMID: 34492704

3. Wu, R. et al. (2024) ACS chemical biology 19, 1544-1553. PMID: 38915184

4. Sherman, EA. et al. (2008) American journal of human genetics 83, 604-9. PMID: 18926513

Примечание

For research use only.

Изображения

Western blot

Western blot analysis was performed using anti-SYGCT polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse kidney lysate

Ссылки

Даташит

Anti-Human SUGCT Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

Антитела

Наборы для анализа

Anti-Human SUGCT Polyclonal Antibody (HA129014)

Обзор

Изображения

Ссылки

Даташит

SDS