

| Numéro de catalogue | HT423014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Reactivité des espèces | Human | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human SULT1C2 (Lys12-Leu296). | ||||||||
| Cible | SULT1C2, humSULTC2, Sulfotransferase 1C1, ST1C2, SULT1C#1, SULT1C1, Sulfotransferase 1C2 | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | O00338 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | Sulfotransferase 1C2 (SULT1C2) is a ~34 kDa protein. Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the sulfate conjugation of phenolic compounds. Does not transfer sulfate to steroids, dopamine, acetaminophen, or alpha-naphthol. Except in mitochondria, where it can add sulfate to cholesterol producing cholesterol sulfate, which alters mitochondrial membrane organization, and impacts protein complex mobility increasing state-III respiration, thereby modulating mitochondrial respiration. Catalyzes the sulfation of the carcinogenic N-hydroxy-2-acetylaminofluorene leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis. 1. Hehonah, N. et al. (1999) The international journal of biochemistry & cell biology 31, 869-82. PMID: 10481272 2. Freimuth, RR. et al. (2000) Genomics 65, 157-65. PMID: 10783263 3. Sakakibara, Y. et al. (1998) The Journal of biological chemistry 273, 33929-35. PMID: 9852044 | ||||||||
| Note | For research use only. |
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